I8529

Insulin-like Growth Factor Binding Protein-5 human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• Synonym(e): IGFBP-5
• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD03457235

Eigenschaften

• biological source: human
• Quality Level: 100
• recombinant: expressed in NSO cells
• assay: >90% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.5-1.5 mg per mL ED₅₀
• mol wt: 34 kDa by SDS-PAGE (reducing), calculated mol wt ~28 kDa
• packaging: pkg of 25 μg
• impurities: endotoxin, tested
• UniProt accession no.: P24593
• storage temp.: −20°C
• Gene Information: human ... IGFBP5(3488)

Beschreibung

General description

The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.[1]

Biochem/physiol Actions

Binds to bone cells and is the predominant insulin-like growth factor binding protein in bone; when binding the extracellular matrix, it modulates IGF activity.

IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions.[2] It also plays a crucial role in cancer progression.[3]

IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)