I1771

Interleukin-13 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonym(e): IL-13
• CAS-Nummer: 148157-34-0
• MDL-Nummer: MFCD00212209
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Assay: ≥97% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: <10.000 ng/mL ED₅₀
• Mol-Gew.: 12 kDa
• Verpackung: pkg of 10 μg
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested
• Farbe: white
• UniProt-Hinterlegungsnummer: P35225
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IL13(3596)

Beschreibung

Biochem./physiol. Wirkung

IL-13 is known to be overexpressed in glioblastoma tumors and cell lines.[1] Elevated IL-13 expression is also observed in parasitic infections.[2] It stimulates fibrosis in many infectious diseases,[3] and acts as a profibrogenic factor.[2]

Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)