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Merck

I0908

Insulin

meets USP testing specifications

Synonym(e):

Human insulin

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I0908-50MG

€ 197,00

I0908-250MG

€ 354,00

€ 197,00


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Über diesen Artikel

Empirische Formel (Hill-System):
C257H383N65O77S6
CAS-Nummer:
Molekulargewicht:
5807.57
UNSPSC Code:
51183600
NACRES:
NA.21
EC Number:
234-279-7
MDL number:
Form:
solid
Biological source:
human
Recombinant:
expressed in Saccharomyces cerevisiae

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Unterstützung erhalten

biological source

human

Quality Level

recombinant

expressed in Saccharomyces cerevisiae

agency

meets USP testing specifications

form

solid

potency

≥27.5 units/mg (dry)

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

application(s)

pharmaceutical (small molecule)

storage temp.

−20°C

InChI key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Gene Information

human ... INS(3630)

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Dieser Artikel
1342106I031000011376497001
vibrant-m

I0310000

Insulin human

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | mammalian: suitable

biological source

human

biological source

-

biological source

-

biological source

-

recombinant

expressed in Saccharomyces cerevisiae

recombinant

-

recombinant

-

recombinant

-

form

solid

form

-

form

-

form

lyophilized (clear, colorless solution after reconstitution)

UniProt accession no.

P01308

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

P01308

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

Biochem/physiol Actions

Reguliert die zelluläre Aufnahme, Nutzung und Speicherung von Glukose, Aminosäuren und Fettsäuren und hemmt den Abbau von Glykogen, Protein und Fett.
Zweikettiges Polypeptidhormon, das von den β-Zellen der Langerhans-Inseln produziert wird. Sein Molekulargewicht ist ~ 5800 Da. Die α- und β-Ketten sind durch zwei Disulfidbrücken zwischen den Ketten verbunden. Die α-Kette enthält eine Disulfidbrücke innerhalb der Kette. Insulin reguliert die zelluläre Aufnahme, Nutzung und Speicherung von Glukose, Aminosäuren und Fettsäuren und hemmt den Abbau von Glykogen, Protein und Fett.

Other Notes

InChI: 1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1

Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Marius Hervé et al.
Scientific reports, 12(1), 13191-13191 (2022-08-02)
We present experiments where extreme ultraviolet femtosecond light pulses are used to photoexcite large molecular ions at high internal energy. This is done by combining an electrospray ionization source and a mass spectrometer with a pulsed light source based on
Wei-Chieh Mu et al.
Nutrients, 10(7) (2018-07-20)
Aging is the main factor involved in the onset of degenerative diseases. Dietary protein restriction has been shown to increase the lifespan of rodents and improve metabolic phenotype. Branched-chain amino acids (BCAA) can act as nutrient signals that increase the
Carolyn Shembrey et al.
Cancers, 14(3) (2022-02-16)
Geno- and phenotypic heterogeneity amongst cancer cell subpopulations are established drivers of treatment resistance and tumour recurrence. However, due to the technical difficulty associated with studying such intra-tumoural heterogeneity, this phenomenon is seldom interrogated in conventional cell culture models. Here
Benoit You et al.
EBioMedicine, 51, 102574-102574 (2019-12-27)
In colorectal cancer, hPG80 (progastrin) is released from tumor cells, promotes cancer stem cells (CSC) self-renewal and is detected in the blood of patients. Because the gene GAST that encodes hPG80 is a target gene of oncogenic pathways that are
Michael J Abrams et al.
eLife, 10 (2021-12-08)
Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny.

Questions

1–5 of 5 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is this product sterile or not ? Can this be filtered using a 0.22uM filter after being added in the media ?

    1 answer
    1. This product is not sterile. It may be filter sterilized using a low protein binding membrane having a 0.2 μm pore size. Typically, the stock solution is filter sterilized when prepared and added aseptically to the media.
      See the link below to review the product datasheet for the bovine insulin products. While not the same biological source, the general information does apply to the human source product.

      Product Datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/132/262/i6634pis.pdf

      Helpful?

  4. What is the solublity and solution stability for Product I0908, Insulin?

    1 answer
    1. As Product I0908 - Insulin human meets USP specifications, we only report out the USP testing results.  In the USP method, Insulin is dissolved in 0.01N HCl.  Insulin is readily soluble (10-20 mg/ml) in weak acids.For Product I2643, recombinant human insulin, we indicate the following storage conditions. A stock solution can be stored frozen at -20°C in single-use aliquots. Freeze-thaw cycles should be avoided. Alternatively, it can be stored for up to 12 months at 2-8°C, if it is sterile filtered through a low protein binding membrane or if it contains a suitable bacteriostat, such as 0.1% thimerosal or sodium azide.

      Helpful?

  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

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