H6649

Herbimycin A aus Streptomyces hygroscopicus

≥95% (HPLC), powder

• Empirische Formel (Hill-System): C₃₀H₄₂N₂O₉
• CAS-Nummer: 70563-58-5
• Molekulargewicht: 574.66
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 24895756
• MDL number: MFCD00151702
• Beilstein/REAXYS Number: 4834067
• Assay: ≥95% (HPLC)
• Form: powder
• Quality level: 200

Eigenschaften

• biological source: Streptomyces hygroscopicus
• Quality Level: 200
• assay: ≥95% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: 7.5 mg/mL
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
• InChI: 1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
• InChI key: MCAHMSDENAOJFZ-BVXDHVRPSA-N

Beschreibung

General description

DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Herbimycin A from Streptomyces hygroscopicus is a benzoquinoid ansamycin antibiotic.[1] It is an analog of geldanamycin.[2]

Application

Herbimycin A from Streptomyces hygroscopicus has been used as an inhibitor of Src tyrosine kinase in HEK293T cells[3] and rat intestinal epithelial cells.[4] It has also been used to test its attenuation effect in intimal hyperplasia (IH) post balloon injury in rat carotid artery.[1]

Biochem/physiol Actions

An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

Herbimycin A is an inducer of heat shock protein (HSP). It increases HSP expression resulting in the attenuation of ischemia reperfusion induced pulmonary injury.[1]

Disclaimer

Hygroscopic and photosensitive

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• ppe: Eyeshields, Gloves, type N95 (US)