Quality testing of the product does not include the determination of its solubility. Literature indicates the product can be dissolved in DMSO and stored at 2-8°C for 2 weeks or 6 months at -80°C. Because solubility testing is not performed, this claim has not been validated.
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D0565
Digoxin-BSA bovine
lyophilized powder
Synonym(e):
Digoxin-BSA
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Biological source:
bovine
Form:
lyophilized powder
Technique(s):
inhibition assay: suitable
biological source
bovine
form
lyophilized powder
extent of labeling
~10 mol Digoxin per mol albumin
technique(s)
inhibition assay: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
cow ... ALB(280717)
Application
Digoxin-BSA bovine is a cardioactive glycoside which can increase intracellular calcium concentration through Na+/K+-ATPase pump inhibition. Digoxin has been used in treatments of heart related disease and also studies of cancer treatments. It has shown the ability to inhibit prostate cancer cell growth, but has also shown a reduction in the efficiency of chemotherapy (reduced drug absorption) by increasing the amount of P-glycoprotein (Pgp).
Biochem/physiol Actions
Antigen-protein conjugate.
Physical form
Lyophilized from 0.06 M Tris
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| technique(s) inhibition assay: suitable | technique(s) ELISA: suitable, microbiological culture: suitable | technique(s) ELISA: suitable, electrophoresis: suitable, western blot: suitable | technique(s) blood typing: suitable, microbiological culture: suitable |
| biological source bovine | biological source bovine | biological source bovine | biological source bovine |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Gene Information cow ... ALB(280717) | Gene Information bovine ... ALB(280717) | Gene Information bovine ... ALB(280717) | Gene Information bovine ... ALB(280717) |
| extent of labeling ~10 mol Digoxin per mol albumin | extent of labeling - | extent of labeling - | extent of labeling - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chiara Riganti et al.
Toxicology and applied pharmacology, 240(3), 385-392 (2009-08-04)
Digoxin and ouabain are cardioactive glycosides, which inhibit the Na+/K+-ATPase pump and in this way they increase the intracellular concentration of cytosolic calcium ([Ca2+](i)). They are also strong inducers of the P-glycoprotein (Pgp), a transmembrane transporter which extrudes several drugs
S P O'Neill et al.
Journal of immunology (Baltimore, Md. : 1950), 116(2), 363-366 (1976-02-01)
Animals immunized with hapten-protein conjugates subsequently circulate high concentrations of hapten bound by antibody. The levels of hapten detected are capable of significantly reducing antibody titer in the sera immunized animals. In the case of steroid-protein conjugates, the main source
Elizabeth A Platz et al.
Cancer discovery, 1(1), 68-77 (2011-12-06)
Identification of novel indications for commonly prescribed drugs could accelerate translation of therapies. We investigated whether any clinically-used drugs might have utility for treating prostate cancer by coupling an efficient, high-throughput laboratory-based screen and a large, prospective cohort study. In
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D0565-25MG | 04061831157253 |
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What solvent should be used for this product reconstitution? Any specific conditions?
1 answer-
Helpful?
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Is Digoxin covalently conjugated to BSA? Is there any reference available to confirm this information?
1 answer-
The preparation involves the use of the digoxin-hemisuccinate-BSA conjugate, which means that the digoxin is modified to the hemisuccinate and then linked to the BSA, likely through its epsilon-amino group. Further information can be found in the literature: Biol. Pharm. Bull., 23, 906 (2000).
Helpful?
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