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C271

Sigma-Aldrich

CX546

≥98% (HPLC), solid

Synonym(e):

1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine

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10 MG
€ 215,00
50 MG
€ 916,00

€ 215,00

Voraussichtliches Versanddatum14. Mai 2025

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10 MG
€ 215,00
50 MG
€ 916,00

About This Item

Empirische Formel (Hill-System):
C14H17NO3
CAS-Nummer:
215923-54-9
Molekulargewicht:
247.29
MDL-Nummer:
MFCD01860868
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277960
NACRES:
NA.77

€ 215,00

Voraussichtliches Versanddatum14. Mai 2025

Bulk-Bestellung anfordern

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Lagerbedingungen

protect from light

Farbe

white to off-white

Löslichkeit

DMSO: ≥10 mg/mL

Lagertemp.

2-8°C

SMILES String

O=C(N1CCCCC1)c2ccc3OCCOc3c2

InChI

1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2

InChIKey

LJUNPHMOGNFFOS-UHFFFAOYSA-N

Angaben zum Gen

human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)

Allgemeine Beschreibung

CX546, a benzoylpiperidine derivative ampakine[1] is an analog of CX516.[2]

Anwendung

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.[3]

Biochem./physiol. Wirkung

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5).[1] Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.[4]
Positive AMPA glutamate receptor modulator.

Vorsicht

Photosensitive

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000156418
0000135875
0000084540
0000084539

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Die Dokumentenbibliothek aufrufen

Ampakine? CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators
Pellerin L and Magistretti PJ
Journal of Neurochemistry, 92(3), 668-677 (2005)
Hiroaki Sacai et al.
Nature communications, 11(1), 5140-5140 (2020-10-14)
Autism spectrum disorder (ASD) is thought to result from deviation from normal development of neural circuits and synaptic function. Many genes with mutation in ASD patients have been identified. Here we report that two molecules associated with ASD susceptibility, contactin
Laureen D Hachem et al.
Stem cells and development, 26(23), 1675-1681 (2017-09-28)
Transplantation of neural stem/progenitor cells (NSPCs) following spinal cord injury (SCI) is a promising strategy to enhance regeneration but is limited by poor survival of grafted cells. Determining methods to enhance survival of NSPCs is therefore essential. Positive modulation of
Amy C Arai et al.
The Journal of pharmacology and experimental therapeutics, 303(3), 1075-1085 (2002-11-20)
CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured hippocampal neurons, hippocampal excitatory postsynaptic currents, synaptic field potentials, and agonist binding. The two drugs
C Lu et al.
Molecular psychiatry, 21(2), 159-168 (2015-11-26)
Numerous risk genes have recently been implicated in susceptibility to autism and schizophrenia. Translating such genetic findings into disease-relevant neurobiological mechanisms is challenging due to the lack of throughput assays that can be used to assess their functions on an
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