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B1636
Pentagastrin
≥95% (HPLC), powder, CCK2 receptor agonist
Synonym(e):
Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 25 mg | Warenkorb auf Verfügbarkeit prüfen | € 215,00 | |
| 100 mg | Warenkorb auf Verfügbarkeit prüfen | € 714,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C37H49N7O9S
CAS-Nummer:
Molekulargewicht:
767.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
226-889-7
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality level:
Storage condition:
(Keep container tightly closed in a dry and well-ventilated place.)
Technischer Dienst
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Unterstützung erhaltenProduktname
Pentagastrin, ≥95% (HPLC), powder
Quality Level
assay
≥95% (HPLC)
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place.)
color
white to off-white
solubility
DMF: 20 mg/mL, clear, colorless to faint yellow or tan
storage temp.
−20°C
SMILES string
CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
InChI
1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
InChI key
NEYNJQRKHLUJRU-UHFFFAOYSA-N
Gene Information
mouse ... Cckbr(12426)
rat ... Cckar(24889), Cckbr(25706)
General description
Research area: Immunology & cytokines
Application
Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity. It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[1]
Biochem/physiol Actions
Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin. It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[2] Pentagastrin stimulates the secretion of pepsin and gastric acid. It also aids in the evaluation of gastric acid secretory function.[3] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[2]
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Dieser Artikel | |||
|---|---|---|---|
| form powder | form powder | form solid | form film |
| assay ≥95% (HPLC) | assay >90% (HPLC) | assay - | assay ≥95% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition (Keep container tightly closed in a dry and well-ventilated place.) | storage condition - | storage condition - | storage condition desiccated |
| solubility DMF: 20 mg/mL, clear, colorless to faint yellow or tan | solubility 1% ammonia: soluble 1 mg/mL, clear, yellow | solubility - | solubility - |
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Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Katsunori Iijima et al.
Journal of gastroenterology, 47(12), 1290-1297 (2012-05-03)
The association of Helicobacter pylori infection with aspirin-induced gastropathy is controversial. H. pylori infection exerts diverse effects on gastric acid secretion. In this study, the interaction between H. pylori infection and aspirin was investigated with reference to the individual gastric
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement
Erlich J C, et al.
Frontiers in Behavioral Neuroscience, 6(2-3), 16-16 (2012)
Makoto Inada et al.
Scandinavian journal of gastroenterology, 47(2), 148-154 (2012-01-05)
A traditional measurement of gastric acid, involving nasogastric intubation of stomach and acid suction, has been suggested as a gold standard. However, this causes the patient discomfort and cost increase, and is 'time-consuming'. A calcium [(13)C]carbonate (Ca(13)CO(3)) breath test was
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B1636-100MG | 04061832674551 |
| B1636-25MG | 04061833426265 |
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What is the Department of Transportation shipping information for this product?
1 answer-
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What is Pentagastrin, Product B1636, soluble in?
1 answer-
Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.
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How can Pentagastrin, Product B1636, solutions be stored?
1 answer-
Pentagastrin is subject to oxidation in solution. A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.
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What is the shelf-life of Pentagastrin, Product B1636?
1 answer-
This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.
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