A7980

AC-41848 hydrate

≥98% (HPLC), solid

• Synonym(e): 1-[(2,4-Dichlorophenyl)methyl]-6,7,8,9-tetrahydro-3-phenyl-5H-imidazo[1,2-a]azepinium bromide hydrate
• Empirische Formel (Hill-System): C₂₁H₂₁BrCl₂N₂ · xH₂O
• CAS-Nummer: 400856-69-1
• Molekulargewicht: 452.21 (anhydrous basis)
• MDL-Nummer: MFCD08705316
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724399
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated; under inert gas
• Löslichkeit: DMSO: ~14 mg/mL; H₂O: >5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [Br-].[H]O[H].Clc1ccc(C[n+]2cc(-c3ccccc3)n4CCCCCc24)c(Cl)c1
• InChI: 1S/C21H21Cl2N2.BrH.H2O/c22-18-11-10-17(19(23)13-18)14-24-15-20(16-7-3-1-4-8-16)25-12-6-2-5-9-21(24)25;;/h1,3-4,7-8,10-11,13,15H,2,5-6,9,12,14H2;1H;1H2/q+1;;/p-1
• InChIKey: FPOBEBBUBSFIIA-UHFFFAOYSA-M

Beschreibung

Anwendung

AC-41848 is a potent, cell permeable, and subtype selective retinoic acid receptor RARγ agonist.

Biochem./physiol. Wirkung

AC-41848 is a potent, cell permeable, subtype selective retinoic acid receptor RARγ agonist. AC-41848 has high selectivity (92%) for RARγ. EC₅₀ = 5.9 μM.

Potent, cell permeable, subtype selective retinoic acid receptor RARγ agonist. High selectivity (92%) for RARγ. EC₅₀ = 5.9 μM.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves