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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 131,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C20H20ClN3S·2HCl · xH2O
CAS-Nummer:
Molekulargewicht:
442.83 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: ≥5 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
SMILES string
O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1
InChI
1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2
InChI key
QOPATWWWZNTSQF-UHFFFAOYSA-N
Application
ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.
Biochem/physiol Actions
ARL-17477 dihydrochloride hydrate is a selective nNOS inhibitor
ARL-17477 is an nNOS specific inhibitor. The IC50 against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Dieser Artikel | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay >98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition desiccated | storage condition desiccated | storage condition - |
| solubility H2O: ≥5 mg/mL | solubility DMSO: 10 mg/mL, clear | solubility DMSO: ≥5 mg/mL | solubility H2O: 1 mg/mL, clear (warmed) |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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