A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

• Synonym(e): Ac-QKLVFF-NH₂, amyloid blocker
• Empirische Formel (Hill-System): C₄₂H₆₃N₉O₈
• CAS-Nummer: 189064-06-0
• Molekulargewicht: 822.01
• MDL-Nummer: MFCD17215285
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329770908
• NACRES: NA.32

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white
• UniProt-Hinterlegungsnummer: P05067
• Lagertemp.: −20°C
• SMILES String: CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O
• InChI: 1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
• InChIKey: DDXTVYDSGCHGAN-PITCCTKHSA-N
• Angaben zum Gen: human ... APP(351)

Beschreibung

Amino Acid Sequence

Ac-Gln-Lys-Leu-Val-Phe-Phe-NH2

Biochem./physiol. Wirkung

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)