A5282

DL-2-Amino-5-phosphono-valeriansäure

≥98% (TLC), solid, NMDA receptor antagonist

• Synonym(e): 5-Phosphono-DL-norvalin, DL-2-Amino-5-Phosphonopentansäure, AP-5, APV
• Empirische Formel (Hill-System): C₅H₁₂NO₅P
• CAS-Nummer: 76326-31-3
• Molekulargewicht: 197.13
• Beilstein: 2446389
• MDL-Nummer: MFCD00010515
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24277950
• NACRES: NA.32

Eigenschaften

• product name: DL-2-Amino-5-phosphono-valeriansäure, solid
• Form: solid
• Farbe: white
• Löslichkeit: 0.1 M NaOH: 4 mg/mL; H₂O: 5.6 mg/mL; organic solvents: insoluble
• SMILES String: NC(CCCP(O)(O)=O)C(O)=O
• InChI: 1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
• InChIKey: VOROEQBFPPIACJ-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Grik1(29559) , Grin2a(24409) , Grin2b(24410)

Beschreibung

Anwendung

DL-2-Amino-5-phosphonopentanoic acid has been used:

• in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses
• used in growth medium for inhibition of electrical activity in the neuronal network
• used to isolate N-methyl-D-aspartate receptors (NMDAR) or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product
• used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

Biochem./physiol. Wirkung

krampflösend; wirksames und selektives NMDA-Rezeptor-Antagonist

Vorsicht

Hygroscopic

Sonstige Hinweise

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves