A1221

AH6809

≥98%, crystalline solid or supercooled liquid

• Synonym(e): 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid
• Empirische Formel (Hill-System): C₁₇H₁₄O₅
• CAS-Nummer: 33458-93-4
• Molekulargewicht: 298.29
• NACRES: NA.77
• PubChem Substance ID: 329770690
• UNSPSC Code: 12352200
• MDL number: MFCD08056083
• Assay: ≥98%
• Form: crystalline solid or supercooled liquid
• Quality level: 100

Eigenschaften

• Quality Level: 100
• assay: ≥98%
• form: crystalline solid or supercooled liquid
• solubility: ethanol: soluble 2.5 mg/mL, DMSO or DMF: soluble 8 mg/mL
• SMILES string: CC(C)Oc1ccc2c(Oc3ccc(cc3C2=O)C(O)=O)c1
• InChI: 1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)
• InChI key: AQFFXPQJLZFABJ-UHFFFAOYSA-N

Beschreibung

Application

AH6809 has been used:

• as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia[1]
• as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines[2]
• as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)[3]

Biochem/physiol Actions

AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.[4]

DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP₁ and EP₂ prostanoid receptors.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)