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85590

Spermin

≥99.0% (GC)

Synonym(e):

N,N′-Bis-(3-aminopropyl)-1,4-diaminobutan, Gerontin, Musculamin, Neuridin

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PackungsgrößeSKUVerfügbarkeitPreis
5 g
Warenkorb auf Verfügbarkeit prüfen
€ 205,00
25 g
Warenkorb auf Verfügbarkeit prüfen
€ 831,00
€ 706,35

Über diesen Artikel

Lineare Formel:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
CAS-Nummer:
71-44-3
Molekulargewicht:
202.34
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
329769392
EC Number:
200-754-2
Beilstein/REAXYS Number:
1750791
MDL number:
MFCD00008215

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Quality Level

200

biological source

microbial, synthetic

assay

≥99.0% (GC)

form

crystalline (chunks)

impurities

≤0.5% spermidine

bp

150 °C/5 mmHg (lit.)

mp

28-30 (lit.)

solubility

water: 0.05 g/mL, clear, colorless

anion traces

carbonate (CO32-): ≤5000 mg/kg

storage temp.

2-8°C

SMILES string

[H]N(CCCN)CCCCN([H])CCCN

InChI

1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2

InChI key

PFNFFQXMRSDOHW-UHFFFAOYSA-N

Application

Spermine, a polycationic biogenic polyamine derived from spermidine, may be used in a wide variety of biological applications as a supplement or regulatory agent.Used as co-matrix with DHB for MALDI-MS of sialylated glycans in negative ion mode.[1]

Biochem/physiol Actions

Gemischter NMDA-Agonist-/Antagonist an der Polyaminstelle. Spielt eine Rolle bei der Zellproliferation und -differenzierung, hemmt die Neuronale Stickstoffmonoxid-Synthase (nNOS).
Gemischter NMDA-Glutamatrezeptor-Agonist/-Antagonist an der Polyaminstelle. In hohen Konzentrationen (1 mM) wurden neuroprotektive Wirkungen beobachtet, bei niedrigeren Konzentrationen tritt dagegen eine Neurotoxizität auf. Verstärkt die Agonistenwirkung an der für Strychnin unempfindlichen Glycin-Stelle. Spielt eine Rolle bei der Zellproliferation und -differenzierung, hemmt die Neuronale Stickstoffmonoxid-Synthase (nNOS).

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Dieser Artikel
S4264S3256S1141
Spermine ≥99.0% (GC)

Sigma-Aldrich

85590

Spermine

Spermine suitable for cell culture, BioReagent

Sigma-Aldrich

S4264

Spermine

Spermine ≥97%

Sigma-Aldrich

S3256

Spermine

Spermine tetrahydrochloride BioReagent, Molecular Biology

Sigma-Aldrich

S1141

Spermine tetrahydrochloride

biological source

microbial, synthetic

biological source

microbial, synthetic

biological source

microbial, synthetic

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

crystalline (chunks)

form

semisolid

form

-

form

solid

solubility

water: 0.05 g/mL, clear, colorless

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL, clear, colorless

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

mp

28-30 (lit.)

mp

28-30 (lit.)

mp

28-30 (lit.)

mp

310-311 °C (dec.) (lit.)

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pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Lagerklasse

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCP4672
BCCN7109
BCCN4101
BCCN0639
BCCL3738

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Verwandter Inhalt

Glycobiology Brochure

Glycobiology and Glycoproteomics Brochure

Y Mechref et al.
Journal of the American Society for Mass Spectrometry, 9(12), 1293-1302 (1998-12-03)
Negative-ion matrix-assisted laser desorption/ionization mass spectra of sialyated glycoconjugates were acquired employing 2,5-dihydroxybenzoic acid (DHB) in conjunction with spermine as a co-matrix. The addition of spermine to DHB permitted an improved crystal formation as well as a higher analyte solubility.
Nicole K L Lee et al.
Journal of cellular physiology, 226(6), 1453-1460 (2011-03-18)
The naturally occurring polyamines, spermidine, spermine, and their precursor putrescine, play indispensible roles in both prokaryotic and eukaryotic cells, from basic DNA synthesis to regulation of cell proliferation and differentiation. The rate-limiting polyamine biosynthetic enzymes, ornithine decarboxylase (ODC) and S-adenosylmethionine
H Hosseinkhani et al.
Gene therapy, 11(2), 194-203 (2004-01-09)
Dextran-spermine cationic polysaccharide was prepared by means of reductive amination between oxidized dextran and the natural oligoamine spermine. The formed Schiff-base imine-based conjugate was reduced with borohydride to obtain the stable amine-based conjugate. The transfection efficiency of the synthetic dextran-spermine
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Global Trade Item Number

SKUGTIN
85590-5G04061833026168
85590-25G04061833026151

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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