68957

Tris(2-carboxyethyl)phosphin -hydrochlorid

BioUltra, suitable for electrophoresis, SDS-PAGE tested

• Synonym(e): TCEP
• Empirische Formel (Hill-System): C₉H₁₅O₆P · HCl
• CAS-Nummer: 51805-45-9
• Molekulargewicht: 286.65
• UNSPSC Code: 12352128
• NACRES: NA.32
• PubChem Substance ID: 329761275
• MDL number: MFCD00145469
• Beilstein/REAXYS Number: 3724376
• Assay: 97.5-102.5%
• Form: powder

Eigenschaften

• product line: BioUltra
• Quality Segment: 100
• assay: 97.5-102.5%
• form: powder
• mol wt: 286.65 g/mol
• concentration: 90-100 % (w/w) (Tris(2-carboxyethyl)phosphine hydrochloride)
• technique(s): electrophoresis: suitable
• color: white
• mp: 175-177 °C
• solubility: H₂O: soluble
• density: 1.041 g/cm³ at 25 °C
• suitability: SDS-PAGE tested
• SMILES string: Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O
• InChI: 1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H
• InChI key: PBVAJRFEEOIAGW-UHFFFAOYSA-N

Beschreibung

General description

Tris(2-carboxyethyl) phosphine hydrochloride (TCEP.HCL ) is a useful reducing agent for Sulphur and nitrogen-containing compounds. TCEP.HCL and the resultant oxide are water-soluble. [1] TCEP.HCL has electron-rich phosphorus and oxygen atoms to combine with various metals, including Rh, Ir, and Pd. It rapidly complexes with Rh and Ir in dioxane at ambient temperature.[2] It reduces disulfide linkages in a range of peptides and proteins in biological disulfide.[1]

Application

Wasserlösliches Reagenz zur selektiven Reduktion von Disulfiden. Stabiler als DDT und nützlich für massenspektrometrische Anwendungen.

TCEP.HCL has been used in various bioconjugation applications, both in vitro and in vivo, to tag proteins and live organisms with great effectiveness under mild physiological circumstances.[3] TCEP.HCL is suitable for varied biological and synthetic applications. At an acidic pH, TCEP.HCL can be used to convert organic disulfides to thiols in water irreversibly.[1]

Features and Benefits

The product has the following benefits:

• TCEP.HCL lowers reactive oxygen species levels.[3]
• It increases glutathione levels and mitochondrial content.[3]
• It has anti-cancer effects.[2]

Analysis Note

agarose gel electrophorese corresponds to requirements

Sicherheitshinweise

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Lagerklasse: 8A - Combustible corrosive hazardous materials
• wgk: WGK 1