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B018

WB-4101 -hydrochlorid

Name: WB-4101 -hydrochlorid
Brand: SIAL

analytical standard

Synonym(e):

2-[(2,6-Dimethoxyphenoxyethyl)-aminomethyl]-1,4-benzodioxan -hydrochlorid

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About This Item

Empirische Formel (Hill-System):

C₁₉H₂₃NO₅ · HCl

CAS-Nummer:

2170-58-3

Molekulargewicht:

381.85

EG-Nummer:

218-520-3

MDL-Nummer:

MFCD00055187

UNSPSC-Code:

41116107

PubChem Substanz-ID:

329773098

NACRES:

NA.24

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Qualität

analytical standard

Qualitätsniveau

100

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Format

neat

SMILES String

Cl.COc1cccc(OC)c1OCCNCC2COc3ccccc3O2

InChI

1S/C19H23NO5.ClH/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14;/h3-9,14,20H,10-13H2,1-2H3;1H

InChIKey

KAHMEWANVDFFCQ-UHFFFAOYSA-N

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

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alpha-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes.

K Ichishima et al.

British journal of pharmacology, 161(1), 193-206 (2010-08-20)

Volume-regulated anion channels (VRACs) play an important role in cell-volume regulation. alpha(1)-Adrenoceptor stimulation by phenylephrine (PE) suppressed the hypotonic activation of VRAC current in mouse ventricular cells and regulatory volume decrease (RVD) was also absent in PE-treated cells. We examined

Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels.

W-X Yuan et al.

Neuroscience, 158(4), 1616-1624 (2008-12-11)

Activation of the descending noradrenergic system inhibits nociceptive transmission in the spinal cord. Although both alpha(1)- and alpha(2)-adrenoceptors in the spinal cord are involved in the modulation of nociceptive transmission, it is not clear how alpha(1)-adrenoceptors regulate excitatory and inhibitory

Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms.

Josie R T Silva et al.

The journal of pain : official journal of the American Pain Society, 12(1), 51-60 (2010-06-18)

We evaluated the effectiveness of intrathecal antagonists of α1- (WB4101) and α2- (idazoxan) adrenoceptors and serotonergic (methysergide), opioid (naloxone), muscarinic (atropine), GABA(A) (bicuculline) and GABA(B) (phaclofen) receptors in blocking 2- or 100-Hz electroacupuncture (EA)-induced analgesia (EAIA) in the rat tail-flick

Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selective α1B-adrenoceptor antagonist.

Laura Fumagalli et al.

European journal of medicinal chemistry, 58, 184-191 (2012-11-06)

Unichiral 8-substituted analogues of 2-[(2-(2,6-dimethoxyphenoxy)ethyl)aminomethyl]-1,4-benzodioxane (WB4101) were synthesized and tested for binding affinity at cloned human α(1a)-, α(1b)-and α(1d)-adrenoreceptor (α(1a)-, α(1b)-and α(1d)-AR) and at native rat 5-HT(1A) receptor and for antagonist affinity at α(1A)-, α(1B)-and α(1D)-AR and at α(2A/D)-AR. Among

Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.

Jin O-Uchi et al.

Circulation research, 102(11), 1378-1388 (2008-05-10)

We examined the effect of alpha(1)-adrenoceptor subtype-specific stimulation on L-type Ca2+ current (I(Ca)) and elucidated the subtype-specific intracellular mechanisms for the regulation of L-type Ca2+ channels in isolated rat ventricular myocytes. We confirmed the protein expression of alpha(1A)- and alpha(1B)-adrenoceptor

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Dokumente

WB-4101 -hydrochlorid

analytical standard

About This Item

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Eigenschaften

Qualität

Qualitätsniveau

Methode(n)

Format

SMILES String

InChI

InChIKey

Beschreibung

Anwendung

Sicherheitshinweise

Lagerklassenschlüssel

WGK

Flammpunkt (°F)

Flammpunkt (°C)

Persönliche Schutzausrüstung

Dokumentation

Analysenzertifikate (COA)

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Peer-Reviewed-Artikel

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