8.51021

N₃-(PEG)₇-COOH (33 atoms)

Novabiochem^®

• Synonym(e): N₃-(PEG)₇-COOH (33 atoms), O-(2-Azidoethyl)-O′-(N-diglycolyl-2-aminoethyl)-heptaethyleneglycol
• Empirische Formel (Hill-System): C₂₂H₄₂N₄O₁₂
• CAS-Nummer: 846549-37-9
• Molekulargewicht: 554.59
• UNSPSC Code: 12352106
• NACRES: NA.22
• MDL number: MFCD10001327
• Assay: ≥97.0% (HPLC)
• Form: oil

Eigenschaften

• Quality Segment: 400
• product line: Novabiochem^®
• assay: ≥97.0% (HPLC)
• form: oil
• reaction suitability: reaction type: click chemistry
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: [N+](=[N-])=NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)COCC(=O)O
• InChI: 1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)
• InChI key: WWDNBBVPYDZICO-UHFFFAOYSA-N

Beschreibung

General description

This building block is prepared from highly purified PEG to ensure homogeneous products free from contaminating PEG oligomers. In this derivative the azido group acts as an orthogonally masked amine; it is stable to both TFA and piperidine but is easily converted to an amine by treatment with phosphines or thiols. For a similar spacer, see reference ^[1]. This material is now only available as an oil.

Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

Literature references
^[1] J. Mack, et al. (1999) J. Peptide Sci., 6, 135.

Analysis Note

Color (visual): slight yellow to yellow
Appearance of substance (visual): oil
Assay (HPLC, area%): ≥ 97.0 % (a/a)

Other Notes

Replaces: 01-63-0103

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H315,H319,H335