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525276

Phosphoramidon-Dinatriumsalz

Inhibits some metalloendopeptidases.

Synonym(e):

Phosphoramidon-Dinatriumsalz, N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na

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PackungsgrößeSKUVerfügbarkeitPreis
5 mg
Warenkorb auf Verfügbarkeit prüfen
€ 242,00

Über diesen Artikel

Empirische Formel (Hill-System):
C23H32N3O10P · 2Na
Molekulargewicht:
587.47
NACRES:
NA.77
UNSPSC Code:
12352202
Form:
lyophilized solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

€ 242,00

Warenkorb auf Verfügbarkeit prüfen
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Unterstützung erhalten

Quality Level

100

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

DMSO: 10 mg/mL, methanol: soluble, water: soluble

shipped in

ambient

storage temp.

2-8°C

General description

Effektive Konzentration: 1–10 µ;M.
Hemmt manche Metalloendopeptidasen. Hochgradig spezifischer Inhibitor von Thermolysin. Hemmt die Umwandlung von Groß-Endothelin-1 in Endothelin (IC50 = 4,6 µ;M).

Biochem/physiol Actions

Zellpermeabel: nein
Primärziel
Thermolysin
Produkt konkurriert nicht mit ATP.
Reversibel: nein
Ziel-IC50: 4,6 µ;M gegen die Umwandlung von Groß-Endothelin-1 in Endothelin

Analysis Note

Einzelpunkt mittels TLC.

Other Notes

Balwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
Howell, S., et al. 1993. Biochem. J. 290, 159.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxizität: Standard-Handhabung (A)

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Phosphoramidon, Disodium Salt Inhibits some metalloendopeptidases.

Sigma-Aldrich

525276

Phosphoramidon, Disodium Salt

Pamidronate, Disodium Salt A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

Sigma-Aldrich

506600

Pamidronate, Disodium Salt

S-Methyl-L-thiocitrulline, Dihydrochloride A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).

Millipore

472804

S-Methyl-L-thiocitrulline, Dihydrochloride

DIDS, Disodium Salt Binds covalently and irreversibly to the outer surface of human erythrocyte membranes.

Sigma-Aldrich

309795

DIDS, Disodium Salt

form

lyophilized solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 10 mg/mL, water: soluble, methanol: soluble

solubility

water: 10 mg/mL

solubility

water: 50 mg/mL

solubility

water: 0.5%

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated, protect from light

Lagerklasse

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Jan Perner et al.
Frontiers in cellular and infection microbiology, 10, 563349-563349 (2020-12-15)
During feeding on vertebrate hosts, ticks secrete saliva composed of a rich cocktail of bioactive molecules modulating host immune responses. Although most of the proteinaceous fraction of tick saliva is of little immunogenicity, repeated feeding of ticks on mammalian hosts
S Howell et al.
The Biochemical journal, 290 ( Pt 1), 159-164 (1993-02-15)
Five membrane peptidase activities have been identified on cultured human osteoblast-like cells. These consisted of the four exopeptidases aminopeptidase-A, aminopeptidase-N, aminopeptidase-W and carboxypeptidase-M, and the endopeptidase, endopeptidase-24.11. The presence of endopeptidase-24.11 was confirmed immunochemically by immunofluorescent staining and by enzyme-linked
J L Balwierczak et al.
Biochemical pharmacology, 49(3), 291-296 (1995-01-31)
The enzyme responsible for the conversion of exogenous big endothelin-1 to endothelin-1 by porcine coronary arterial smooth muscle has been shown to be a metalloprotease. The potencies of eight metalloprotease inhibitors for this endothelin-converting enzyme were determined. CGS 25015, CGS

Global Trade Item Number

SKUGTIN
525276-5MG04055977270648

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