5.05207

Mecamylamine Hydrochloride

• Synonym(e): Mecamylamine Hydrochloride, N,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
• Empirische Formel (Hill-System): C₁₁H₂₁N · xHCl
• CAS-Nummer: 826-39-1
• Molekulargewicht: 167.29 (free base basis)
• UNSPSC Code: 12352116
• NACRES: NA.77
• MDL number: MFCD00151462
• Assay: ≥98% (TLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Eigenschaften

• assay: ≥98% (TLC)
• Quality Level: 100
• form: solid
• potency: 640 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: H₂O: 100 mM
• storage temp.: 2-8°C
• SMILES string: [Cl-].N(C1(C2CC(C1(C)C)CC2)C)C.[H+]
• InChI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
• InChI key: PKVZBNCYEICAQP-UHFFFAOYSA-N

Beschreibung

General description

A potent, nonselective, and noncompetitive antagonist of nAChRs (IC₅₀ = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette′s syndrome, Schizophrenia and various cognitive and mood disorders).

Biochem/physiol Actions

Primary Target
nAChR

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Harris, C., et al. 2013. Psychopharmacol.225, 291.
Lima, H., et al. 2013. Learning & Memory20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects