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490070

Nitric Oxide Synthase, Neuronal Inhibitor I

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Synonym(e):

Nitric Oxide Synthase, Neuronal Inhibitor I, (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA

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PackungsgrößeSKUVerfügbarkeitPreis
5 mg
Warenkorb auf Verfügbarkeit prüfen
€ 443,00

Über diesen Artikel

Empirische Formel (Hill-System):
C8H21N7O2 · 3C2HF3O2 · 2H2O
CAS-Nummer:
Molekulargewicht:
625.40
UNSPSC Code:
12352303
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

€ 443,00


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Quality Segment

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white to off-white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.FC(F)(F)C(=O)O.[N+](=O)(N\C(=N\CCC[C@H](N)CNCCN)\N)[O-]

InChI

1S/C8H21N7O2.3C2HF3O2/c9-3-5-12-6-7(10)2-1-4-13-8(11)14-15(16)17;3*3-2(4,5)1(6)7/h7,12H,1-6,9-10H2,(H3,11,13,14);3*(H,6,7)/t7-;;;/m0.../s1

InChI key

NYWNMNBIORWOSQ-QTPLPEIMSA-N

General description

A cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (Ki = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.
A cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (Ki = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
nNOS
Product does not compete with ATP.
Reversible: no
Target Ki: 120 nM against nNOS

Packaging

Packaged under inert gas

Physical form

Supplied as a dihydrate.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hah, J.M., et al. 2001. J. Med. Chem.44, 2667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Dieser Artikel
324759361549444252
form

solid

form

solid

form

solid

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

water: 1 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 5 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 100 mg/mL


Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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Verwandter Inhalt

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."






Global Trade Item Number

SKUGTIN
490070-5MG04055977273410

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