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Merck

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443300

MCI-186

A free radical scavenger and antioxidant that reduces post-ischemic brain injury.

Synonym(e):

MCI-186

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PackungsgrößeSKUVerfügbarkeitPreis
500 mg
Warenkorb auf Verfügbarkeit prüfen
€ 118,00

Über diesen Artikel

Empirische Formel (Hill-System):
C10H10N2O
CAS-Nummer:
Molekulargewicht:
174.20
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light

€ 118,00


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Quality Level

description

Merck USA index - 14, 6713

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

cream

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

InChI key

QELUYTUMUWHWMC-UHFFFAOYSA-N

General description

Ein Scavenger für freie Radikale und Antioxidans, das postischämische Hirnschädigungen verringert Hemmt die eisenabhängige Peroxidation in Homogenaten des Rattenhirns (IC50 = 15 µ;M). Hemmt die mitochondriale Permeabilitätsübergangspore.

Biochem/physiol Actions

Ziel-IC50: 15 µ;M hemmt die eisenabhängige Peroxidation in Homogenaten des Rattenhirns
Primärziel
Ein Scavenger für freie Radikale und Antioxidans
Produkt konkurriert nicht mit ATP.
Reversibel: nein
Zellpermeabel: nein

Packaging

Verpackt unter inertem Gas

Preparation Note

Nach der Rekonstitution in Aliquote aufteilen und einfrieren (-20 °;C). Stammlösungen sind bei -20 °;C bis zu 3 Monate haltbar.

Other Notes

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxizität: Gesundheitsschädlich (C)

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Dieser Artikel
475856373402324761
form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥99% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated, protect from light


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Lagerklasse

11 - Combustible Solids

wgk

WGK 1



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Verwandter Inhalt

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."





Global Trade Item Number

SKUGTIN
443300-500MG04055977205350

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