This product is tested for solubility in water at 10 mg/mL. Following reconstitution, aliquoting and freezing at -20°C is recommended. Stock solutions remain stable for up to 1 month at -20°C.
420318
Kainsäure
≥98% (HPLC), solid, amino acid receptor agonist, Calbiochem®
Synonym(e):
Kainsäure, 2-Carboxy-4-(1-methylethenyl)-3-pyrrolidin-Essigsäure
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 10 mg | Warenkorb auf Verfügbarkeit prüfen | € 340,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C10H15NO4
CAS-Nummer:
Molekulargewicht:
213.23
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.77
Technischer Dienst
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Unterstützung erhaltenProduktname
Kainsäure, An excitatory amino acid receptor agonist selective for the kainate receptor subtype (Ki = 21 nM for ³H-kainate binding in rat striatum).
Quality Level
description
Merck USA index - 14, 5276
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
dilute base: 10 mg/mL, water: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[N+H2]1[C@@H]([C@H]([C@H](C1)C(=C)C)CC(=O)O)C(=O)[O-]
InChI
1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChI key
VLSMHEGGTFMBBZ-OOZYFLPDSA-N
General description
Ein für den Kainat-Rezeptor-Subtypen selektiver Rezeptor-Agonist für exzitatorische Aminosäuren (Ki = 21 nM für die 3H-Kainatbindung im Striatum von Ratten). Zudem aktiviert es auch die AMPA-Rezeptoren.
Biochem/physiol Actions
Primärziel
Kainat-Rezeptor-Subtyp
Kainat-Rezeptor-Subtyp
Produkt konkurriert nicht mit ATP.
Reversibel: nein
Zellpermeabel: nein
Ziel Ki: 21 nM für die 3H-Kainatbindung im Stratium von Ratten
Other Notes
Niu, L., et al. 1996. Biochemistry35, 2030.
Watkins, J.C. und Evans, R.H. 1981. Annu. Rev. Pharmacol. Toxicol. 21, 165.
Watkins, J.C. und Evans, R.H. 1981. Annu. Rev. Pharmacol. Toxicol. 21, 165.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxizität: Gesundheitsschädlich (C)
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Dieser Artikel | |||
|---|---|---|---|
| form solid | form powder | form powder | form solid |
| assay ≥98% (HPLC) | assay ≥99% (TLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility dilute base: 10 mg/mL, water: 10 mg/mL | solubility H2O: soluble | solubility H2O: >10 mg/mL | solubility DMSO: 10 mg/mL, ethanol: 10 mg/mL, methanol: 10 mg/mL |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Analysenzertifikate (COA)
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Verwandter Inhalt
Glutamate is an excitatory neurotransmitter found in the synaptic vesicles of glutamatergic synapses. The post-synaptic neurons in these synapses contain ionotropic and metabotropic glutamate receptors. Glutamate binds to AMPA (α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid) subtype glutamate receptors, leading to sodium influx into the post-synaptic cell and resulting in neuronal excitability and synaptic transmission. The NMDA (N-methyl-d-aspartate) subtype glutamate receptors, on the other hand, regulate synaptic plasticity, and can influence learning and memory. The metabotropic g-protein coupled mGluRs modulate downstream calcium signaling pathways and indirectly influence the synapse’s excitability. The synaptic architecture includes intracellular scaffolding proteins (PSD-95, GRIP), intercellular cell adhesion molecules (NCAMs, N-Cadherins), and a variety of signaling proteins (CaMKII/PKA, PP1/PP2B). Processes critical for synaptic transmission and plasticity are influenced by these molecules and their interactions. When the function of these molecules is disrupted, it leads to synaptic dysfunction and degeneration, and can contribute to dementia as seen in Alzheimer’s disease.
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Human patients often experience an episode of serious seizure activity, such as status epilepticus (SE), prior to the onset of temporal lobe epilepsy (TLE), suggesting that SE can trigger the development of epilepsy. Yet, the underlying mechanisms are not fully
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Mechanisms governing how immune cells and their derived molecules impact homeostatic brain function are still poorly understood. Here, we elucidate neuronal mechanisms underlying T cell effects on synaptic function and episodic memory. Depletion of CD4 T cells led to memory deficits and
Joshua D Rieskamp et al.
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Within the adult mammalian dentate gyrus (DG) of the hippocampus, glutamate stimulates neural stem cell (NSC) self-renewing proliferation, providing a link between adult neurogenesis and local circuit activity. Here, we show that glutamate-induced self-renewal of adult DG NSCs requires glutamate
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 420318-10MG | 04055977211016 |
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