K2389

Kainic acid monohydrate

From Digenea simplex, ≥98% (HPLC), Kainate glutamate receptor agonist, powder

• Synonym(e): 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
• Empirische Formel (Hill-System): C₁₀H₁₅NO₄ · H₂O
• CAS-Nummer: 58002-62-3
• Molekulargewicht: 231.25
• UNSPSC Code: 12352106
• PubChem Substance ID: 24724520
• NACRES: NA.77
• MDL number: MFCD00150833
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Kainic acid monohydrate, ≥98% (HPLC), from Digenea simplex
• biological source: Digenea simplex
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: H₂O: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• InChI key: FZNZRJRSYLQHLT-SLGZUKMRSA-N

Beschreibung

Application

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Biochem/physiol Actions

Agonist for kainate class of ionotropic glutamate receptors.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)