384620

Honokiol

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

• Synonym(e): Honokiol, 5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV
• Empirische Formel (Hill-System): C₁₈H₁₈O₂
• CAS-Nummer: 35354-74-6
• Molekulargewicht: 266.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00016674
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Level: 100
• description: Merck USA index - 14, 4742
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 10 mg/mL, ethanol: soluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Oc1c(cc(cc1)c2c(ccc(c2)CC=C)O)CC=C
• InChI: 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
• InChI key: FVYXIJYOAGAUQK-UHFFFAOYSA-N

Beschreibung

General description

A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking VEGFR2 autophosphorylation and subsequent rac activation. Also blocks the in vivo growth of SVR angiosarcoma in nude mice.

The active principle of Magnolia extracts that exhibits anti-angiogenic, anti-tumor, anxiolytic, and chemoprotective properties. Shown to induce apoptosis and preferentially inhibit the growth of primary human endothelial cells over fibroblasts by blocking vascular endothelial growth factor receptor 2 (VEGFR2) autophosphorylation and subsequent rac activation. Also shown to block the growth of SVR angiosarcoma in nude mice.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Anti-angiogenic, anti-tumor and anxiolytic properties

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bai, X., et al. 2003. J. Biol. Chem.278, 35501.
Yang, S.E., et al. 2002. Biochem. Pharmacol.63, 1641.
Son, H.J., et al. 2000. Planta Med.66, 469.
Maruyama, Y., et al. 1998. J. Nat. Prod.61, 135.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H318,H411
• pcodes: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable