382175-M

Histone Deacetylase Inhibitor VIII

The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(e): Histone Deacetylase Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid, HDAC Inhibitor VIII
• Empirische Formel (Hill-System): C₂₂H₃₀N₄O₆
• CAS-Nummer: 1045792-66-2
• Molekulargewicht: 446.50
• MDL number: MFCD17010286
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: beige to light brown
• solubility: DMSO: 50 mg/mL
• storage temp.: 2-8°C
• SMILES string: N(O)C(=O)CCCCCCNC(=O)c1n[o]c(c1)c2ccc(cc2)NC(=O)OC(C)(C)C
• InChI: 1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
• InChI key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable, active site Zn²⁺-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC₅₀ = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC₅₀<1.0 µM).

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kozikowski, A.P., et al. 2008. J. Med. Chem.51, 4370.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable