382172

Histone Deacetylase Inhibitor VI, HNHA

The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase.

• Synonym(e): Histone Deacetylase Inhibitor VI, HNHA, N-Hydroxy-7-(2-naphthylthio)heptanomide
• Empirische Formel (Hill-System): C₁₇H₂₁NO₂S
• CAS-Nummer: 926908-04-5
• Molekulargewicht: 303.42
• MDL number: MFCD10568146
• UNSPSC Code: 12352200
• NACRES: NA.54
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: methanol: 10 mg/mL, DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: S(CCCCCCC(=O)NO)c1cc2c(cc1)cccc2
• InChI: 1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)
• InChI key: KPNNXHVGOKRBEF-UHFFFAOYSA-N

Beschreibung

General description

A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC₅₀ = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun.356, 233.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable