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197900

BEC, Hydrochloride

A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5).

Synonym(e):

BEC, Hydrochloride, (S)-(2-Boronoethyl)-L-cysteine, HCI)

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PackungsgrößeSKUVerfügbarkeitPreis
5 mg
Warenkorb auf Verfügbarkeit prüfen
€ 285,00

Über diesen Artikel

Empirische Formel (Hill-System):
C5H12BNO4S · xHCl
Molekulargewicht:
193.03 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (NMR)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

€ 285,00


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Quality Segment

assay

≥97% (NMR)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A boronic acid based arginine analog that acts as a selective, slow- binding, reversible, competitive transition state inhibitor of arginase type I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). Shown to enhance nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle by inhibiting the activity of arginase. Does not inhibit the activity of nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS.
A boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginases I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). BEC does not inhibit nitric oxide synthase (NOS). Causes significant enhancement of NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue.

Biochem/physiol Actions

Cell permeable: no
Primary Target
arginase 1, arginase 2
Product does not compete with ATP.
Reversible: no
Target Ki: 310 nM for human recombinant type II arginase, pH 7.5

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot, flush with nitrogen, and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C. After thawing, discard any unused portion.

Other Notes

Colleluori, D.M., and Ash, D.E. 2001. Biochemistry40, 9356.
Kim, N.N., et al. 2001. Biochemistry40, 2678.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Dieser Artikel
SML1384472804215921
assay

≥97% (NMR)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥99% (HPLC)

form

solid

form

powder

form

solid

form

crystalline solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

10-30°C

solubility

water: 10 mg/mL

solubility

H2O: 20 mg/mL, clear

solubility

water: 50 mg/mL

solubility

methanol: 10 mg/mL, water: 50 mg/mL


Lagerklasse

11 - Combustible Solids

wgk

WGK 3



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Verwandter Inhalt

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Global Trade Item Number

SKUGTIN
197900-5MG07790788048273

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