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Merck

W1520

WAY-200070

≥98% (HPLC)

Synonym(e):

7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol, 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol

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Über diesen Artikel

Empirische Formel (Hill-System):
C13H8BrNO3
CAS-Nummer:
440122-66-7
Molekulargewicht:
306.11
NACRES:
NA.77
PubChem Substance ID:
329830426
UNSPSC Code:
51111800
MDL number:
MFCD16618385
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

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InChI

1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H

SMILES string

Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2

InChI key

BAAILVWEAXFTSF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

solubility

DMSO: ≥20 mg/mL

originator

Wyeth

storage temp.

2-8°C

Quality Level

100

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Dieser Artikel
SML2527SML2388SML1944
WAY-200070 ≥98% (HPLC)

Sigma-Aldrich

W1520

WAY-200070

SW063058 ≥98% (HPLC)

Sigma-Aldrich

SML2527

SW063058

SW157765 ≥98% (HPLC)

Sigma-Aldrich

SML2388

SW157765

Bz-423 ≥98% (HPLC)

Sigma-Aldrich

SML1944

Bz-423

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

originator

Wyeth

originator

-

originator

-

originator

-

General description

WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Application

WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response.[1][2] WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.[3]

Biochem/physiol Actions

Potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.

Features and Benefits

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H319

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000418300
0000418300
050M4622V

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Die Dokumentenbibliothek aufrufen

Lidia I Serova et al.
The Journal of endocrinology, 205(3), 253-262 (2010-03-30)
Previously, pretreatment with estradiol benzoate (EB) was found to modulate the response of hypothalamic-pituitary-adrenal (HPA) axis and gene expression in several catecholaminergic neuronal locations in ovariectomized (OVX) rats exposed to single immobilization stress (IMO). Here, we investigated the role of
Paloma Alonso-Magdalena et al.
Diabetes, 62(6), 2015-2025 (2013-01-26)
The estrogen receptor β (ERβ) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ERβ selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances
Claus Lattrich et al.
Archives of gynecology and obstetrics, 289(1), 163-171 (2013-08-03)
Coexpression of estrogen receptors (ER) α and β is present in about half of all breast cancer cases. Whereas ERα is a well-established target for endocrine therapy with the selective estrogen receptor modulator tamoxifen, the applicability of ERβ as target
Amy E Clipperton-Allen et al.
Psychoneuroendocrinology, 36(7), 981-995 (2011-01-21)
Gonadal hormones mediate both affiliative and agonistic social interactions. Research in estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice suggests that ERα increases and ERβ decreases male aggression, while the opposite is found for female ERαKO and ERβKO
Matthew D Hale et al.
Biology of reproduction, 100(1), 149-161 (2018-07-17)
Estrogens regulate key aspects of sexual determination and differentiation, and exposure to exogenous estrogens can alter ovarian development. Alligators inhabiting Lake Apopka, FL, are historically exposed to estrogenic endocrine disrupting contaminants and are characterized by a suite of reproductive abnormalities
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