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V106

R(+)-Verapamil monohydrochloride hydrate

≥98% (HPLC), powder

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Über diesen Artikel

Empirische Formel (Hill-System):
C27H38N2O4 · HCl · xH2O
CAS-Nummer:
38176-02-2
Molekulargewicht:
491.06 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24900706
UNSPSC Code:
12161501
EC Number:
205-800-5
MDL number:
MFCD11046028
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

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Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]22/D +9.6°, c = 0.5 in ethanol(lit.)

storage condition

desiccated

color

white

solubility

H2O: >30 mg/mL, ethanol: soluble

SMILES string

O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1

InChI key

ICKXRKHJKXMFLR-KFSCGDPASA-N

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Dieser Artikel
V105M5441D9571
R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

V106

R(+)-Verapamil monohydrochloride hydrate

S(−)-Verapamil hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

V105

S(−)-Verapamil hydrochloride hydrate

Mibefradil dihydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

M5441

Mibefradil dihydrochloride hydrate

Dolasetron mesylate hydrate ≥98% (HPLC), powder

Sigma-Aldrich

D9571

Dolasetron mesylate hydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: >30 mg/mL, ethanol: soluble

solubility

H2O: >30 mg/mL, ethanol: soluble

solubility

H2O: soluble >20 mg/mL, absolute ethanol: insoluble

solubility

H2O: >30 mg/mL

storage condition

desiccated

storage condition

desiccated, protect from light

storage condition

desiccated

storage condition

-

color

white

color

white to beige

color

white

color

white to off-white

Application

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Biochem/physiol Actions

Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.
Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

Disclaimer

hygroscopic

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000221360
0000225380
0000221361
0000221361
0000221360

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Effect of formulation variables on verapamil hydrochloride release from hydrated HPMC matrices
Ramrez C, et al.
Journal of the Mexican Chemical Society, 48(4), 326-331 (2004)
E G Chikhale et al.
The Journal of pharmacology and experimental therapeutics, 273(1), 298-303 (1995-04-01)
When the blood-brain barrier (BBB) transport of a series of model peptides that varied in their physicochemical properties (lipophilicity, size and hydrogen-bonding potential) was determined using an in situ rat brain perfusion technique, an unexpected increase in flux with increasing
Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205
Wu D, et al.
Archives of Biochemistry and Biophysics, 604(1), 74-85 (2016)
Formulation and evaluation of once daily sustained release matrix tablet of verapamil hydrochloride
Ray B and Gupta MM
Journal of Drug Delivery and Therapeutics, 3(1) (2013)
J A Plumb et al.
Biochemical pharmacology, 39(4), 787-792 (1990-02-15)
The L-isomer of verapamil is a more potent calcium antagonist than the D-isomer. We have examined the two stereoisomers of verapamil for their ability to increase the chemosensitivity in vitro of three drug resistant cell lines (2780AD, MCF7/AdrR and H69LX10).
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Global Trade Item Number

SKUGTIN
V106-25MG04061837429095
V106-5MG04061837429101

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