V0377

[Arg⁸]-Vasopressin solution

Grade VI (synthetic), ~100 IU/mL in 0.9% NaCl

• Synonym(e): β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin
• Empirische Formel (Hill-System): C₄₆H₆₅N₁₅O₁₂S₂
• CAS-Nummer: 113-79-1
• Molekulargewicht: 1084.23
• MDL-Nummer: MFCD00076738
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24900692
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Sterilität: non-sterile
• Typ: Grade VI (synthetic)
• Form: liquid
• Enthält: 0.4% 4-chlorobutanol as preservative
• Konzentration: ~100 IU/mL in 0.9% NaCl
• pH-Wert: ~3.5
• UniProt-Hinterlegungsnummer: P01185
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: NC1CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O
• InChI: 1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)
• InChIKey: KBZOIRJILGZLEJ-UHFFFAOYSA-N
• Angaben zum Gen: human ... AVP(551)

Beschreibung

Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Anwendung

[Arg⁸]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry.[1] The product was used in L6 cell culture of the C5 subclone for differentiation studies.[2]

Biochem./physiol. Wirkung

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg⁸-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).

Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.

[Arg⁸]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.[3] It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.[4]

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): 235.4 °F - closed cup
• Flammpunkt (°C): 113 °C - closed cup