U8881

UCL 1684 ditrifluoroacetate hydrate

• Synonym(e): 6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
• Lineare Formel: (C₃₄H₃₀N₄)²⁺ · (C₂F₃O₂^-)₂ · xH₂O
• CAS-Nummer: 201147-19-5
• Molekulargewicht: 720.66 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24900684
• NACRES: NA.77

Eigenschaften

• color: white to off-white
• Quality Segment: 100
• solubility: DMSO: 10 mg/mL
• SMILES string: [H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
• InChI: 1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
• InChI key: YROHEYZVNZITJN-DDVHGCDCSA-N

Beschreibung

Application

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair[1]. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries[2].

Biochem/physiol Actions

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)