U103

U-69593

solid

• Synonym(e): (+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide, U69593
• Empirische Formel (Hill-System): C₂₂H₃₂N₂O₂
• CAS-Nummer: 96744-75-1
• Molekulargewicht: 356.50
• MDL-Nummer: MFCD05664586
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278769
• NACRES: NA.77

Eigenschaften

• Form: solid
• Qualitätsniveau: 100
• Optische Aktivität: [α]/D +7.8°, c = 0.825 in methanol(lit.)
• Farbe: white
• Löslichkeit: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL; 0.1 M HCl: >40 mg/mL; ethanol: >40 mg/mL; 0.1 M NaOH: insoluble; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccccc4
• InChI: 1S/C22H32N2O2/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24/h2-4,8-9,19-20H,5-7,10-17H2,1H3/t19-,20-,22-/m0/s1
• InChIKey: PGZRDDYTKFZSFR-ONTIZHBOSA-N
• Angaben zum Gen: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) ; mouse ... Oprk1(18387) ; rat ... Oprd1(24613) , Oprk1(29335) , Oprm1(25601)

Beschreibung

Biochem./physiol. Wirkung

U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

Leistungsmerkmale und Vorteile

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

U-69593 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (10 mg/ml), 0.1 M HCl (>40 mg/ml), and ethanol (>40 mg/ml). However, it is insoluble in 0.1 M NaOH and water.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)