U105

U-62066

solid

• Synonym(e): (±)-(5α,7α,8β)-3,4-Dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide mesylate salt, Spiradoline mesylate salt
• Lineare Formel: C₂₂H₃₀Cl₂N₂O₂ · CH₃SO₃H
• CAS-Nummer: 87151-85-7
• Molekulargewicht: 521.50
• NACRES: NA.77
• PubChem Substance ID: 24278071
• UNSPSC Code: 12352200
• MDL number: MFCD00153876
• Form: solid

Eigenschaften

• form: solid
• Quality Segment: 200
• color: white
• solubility: H₂O: 14 mg/mL, methanol: insoluble
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccc(Cl)c(Cl)c4
• InChI: 1S/C22H30Cl2N2O2.CH4O3S/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26;1-5(2,3)4/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3;1H3,(H,2,3,4)/t19-,20-,22-;/m0./s1
• InChI key: FHEZDPDAYTVKKG-JLBKCEDKSA-N
• Gene Information: human ... OPRK1(4986)

Beschreibung

Biochem/physiol Actions

U-62066, also known as spiradoline, is a highly selective κ opioid receptor agonist. It exhibits analgesic and diuretic effects.[1] Antitussive property of U-62066 is observed in rats.[2]

Preparation Note

U-62066 is soluble in water at 14 mg/ml, but is insoluble in methanol.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)