T9772

Triazolam

• Synonym(e): 8-Chlor-6-(2-chlorphenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin
• Empirische Formel (Hill-System): C₁₇H₁₂Cl₂N₄
• CAS-Nummer: 28911-01-5
• Molekulargewicht: 343.21
• NACRES: NA.77
• PubChem Substance ID: 24900602
• UNSPSC Code: 12352200
• EC Number: 249-307-3
• MDL number: MFCD00079623

Eigenschaften

• drug control: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland
• solubility: 0.1 M HCl: soluble 1 g in 600 mL solvent, chloroform: soluble 1 g in 25 mL solvent, ethanol: soluble 1 g in 1000 mL solvent, DMSO: soluble 5.4 mg/mL, dichloromethane: 50 mg/mL, clear, colorless to faintly yellow, methanol: soluble 8.8 mg/mL, H₂O: insoluble, diethyl ether: insoluble
• originator: Johnson & Johnson
• SMILES string: ClC1=CC=CC=C1C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C42
• InChI: 1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
• InChI key: JOFWLTCLBGQGBO-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Beschreibung

Application

Triazolam has been used to define nonspecific binding in radioligand binding assays[1]. Triazolam has also been used to study the effects of reducing mPer1 mRNA levels in mouse cerbellum[2].

Biochem/physiol Actions

Anxiolytisch; Ligand für die GABA _A-Rezeptor Benzodiazepin modulatorische Stelle.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Triazolam is soluble in dichloromethane at 50 mg/ml, with heat as needed, yielding a clear, colorless to faint yellow solution. Furthermore, 1g of triazolam is soluble in 25 mL chloroform, 1000 mL ethanol, and 600 mL 0.1 M HCl. It is also soluble in DMSO (5.4 mg/ml) and methanol (8.8 mg/ml). However, it is insoluble in water and in ether.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)