T1019

(±)-Thiopental

• Synonym(e): 5-Ethyl-5-(1-methylbutyl)-2-thiobarbitursäure, Thiopenton
• Empirische Formel (Hill-System): C₁₁H₁₈N₂O₂S
• CAS-Nummer: 76-75-5
• Molekulargewicht: 242.34
• NACRES: NA.77
• PubChem Substance ID: 24899925
• UNSPSC Code: 41116107
• EC Number: 200-984-3
• MDL number: MFCD00057564

Eigenschaften

• drug control: USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
• Quality Segment: 200
• solubility: ethanol: complete 50 mg/mL
• originator: Abbott
• SMILES string: CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
• InChI: 1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
• InChI key: IUJDSEJGGMCXSG-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Beschreibung

Application

(±)-Thiopental was used to transiently anesthetize rats for in vivo NMR spectroscopy.[1]

Biochem/physiol Actions

Thiopental is an anesthetic that decreases cerebral metabolic rate without altering the blood flow or oxygen consumption.[2]

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves