SRP8015

Progranulin mouse

>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized

• Synonym(e): GPx-1, PEPI, Proepithelin
• UNSPSC Code: 12352202
• NACRES: NA.32
• Biological source: mouse
• Recombinant: expressed in HEK 293 cells
• Assay: >95% (SDS-PAGE)
• Form: lyophilized
• Mol wt: ~65 kDa by SDS-PAGE
• Impurities: <0.1 EU/μg endotoxin, tested

Eigenschaften

• Produktname: Progranulin mouse, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)
• biological source: mouse
• recombinant: expressed in HEK 293 cells
• conjugate: untagged
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~65 kDa by SDS-PAGE
• packaging: pkg of 10 μg
• impurities: <0.1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: P28798
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Grn(14824)

Beschreibung

General description

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable