SRP8017

Progranulin rat

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• Synonym(e): PEPI, Proepithelin
• CAS-Nummer: 139316-59-9
• NACRES: NA.32
• UNSPSC Code: 12352202
• Form: lyophilized
• Assay: >95% (SDS-PAGE)
• Biological source: rat
• Recombinant: expressed in HEK 293 cells
• Mol wt: ~65 kDa by SDS-PAGE

Eigenschaften

• biological source: rat
• recombinant: expressed in HEK 293 cells
• tag: FLAG^® tagged
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~65 kDa by SDS-PAGE
• packaging: pkg of 10 μg
• manufacturer/tradename: Sigma-Aldrich
• storage condition: avoid repeated freeze/thaw cycles
• impurities: <0.1 EU/μg endotoxin, tested
• color: white
• UniProt accession no.: P23785
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: rat ... Grn(29143)

Beschreibung

General description

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG^®-tag.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable