SML3070

PSEM89S Hydrochloride salt

≥98% (HPLC)

• Synonym(e): (S)-2,5-Dimethoxy-N-(quinuclidin-3-yl)benzamide, Hydrochloride salt, N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide Hydrochloride salt, PSEM 89S Hydrochloride salt, PSEM-89S Hydrochloride salt
• Empirische Formel (Hill-System): C₁₆H₂₂N₂O₃ · HCl
• CAS-Nummer: 1221570-55-3
• Molekulargewicht: 326.82
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N[C@@H]1CN2CCC1CC2)C3=C(C=CC(OC)=C3)OC.Cl
• InChI: 1S/C16H22N2O3.ClH/c1-20-12-3-4-15(21-2)13(9-12)16(19)17-14-10-18-7-5-11(14)6-8-18;/h3-4,9,11,14H,5-8,10H2,1-2H3,(H,17,19);1H/t14-;/m1./s1
• InChI key: OHMFVSNTNXNVRE-PFEQFJNWSA-N

Beschreibung

Biochem/physiol Actions

PSEM agonist for chimeric ligand-gated ion channel pores with nAChR α7 LBD L141F or L141F/Y115F mutant (PSAM) in vitro and in vivo.

PSEM89S is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML^141F-GlyR & PSAML^141F/Y115F-GlyR). 5-HT3 (PSAML^141F-5-HT3 & PSAML^141F/Y115F-5-HT3) and high-conductance 5-HT3 (PSAML^141F-5-HT3 HC & PSAML^141F/Y115F-5-HT3 HC).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable