This product does not have an assigned shelf life or expiration date. The QC testing date is given on the certificate of analysis for each lot. The standard Sigma-Aldrich guarantee of one year from date of receipt applies.
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R0875
Reserpin
Synonym(e):
(3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carbonsäure-methylester
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1 G
€ 243,00
About This Item
Empirische Formel (Hill-System):
C33H40N2O9
CAS-Nummer:
Molekulargewicht:
608.68
Beilstein:
102014
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
mp (Schmelzpunkt)
~265 °C (dec.)
SMILES String
CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
InChI
1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChIKey
QEVHRUUCFGRFIF-MDEJGZGSSA-N
Angaben zum Gen
human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC18A2(6571)
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Anwendung
Biochem./physiol. Wirkung
Hemmt die vesikuläre Aufnahme von Catecholaminen und Serotonin.
Reserpine is an alkaloid present in Rauwolfia species. It is useful in treating systemic hypertension, schizophrenia, psychiatric disorders[2] and Raynaud′s syndrome.[4] Reserpine is known to inhibit adrenaline induced-cutaneous blood vessel constriction. It diminishes the effect of hyperthyroidism on cardiovascular and nervous system.[4]
Leistungsmerkmale und Vorteile
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
Zielorgane
Central nervous system
Lagerklassenschlüssel
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Analysenzertifikate (COA)
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Artikel
Discover Bioactive Small Molecules for ADME/Tox
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What is the shelf life/expiration date of Product R0875, Reserpine?
1 answer-
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Can solutions of Product R0875, Reserpine, be autoclaved?
1 answer-
You can filter sterilize the solution. Autoclaving is not recommended as it discolors the solution.
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Is Product R0875, Reserpine, soluble in DMSO?
1 answer-
Reserpine can be dissolved in DMSO at 50 mg/mL, according to Stevenson, P.A., et al., J. Neurobiol., 43(2), 107-120 (2000).
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Where do you store Product R0875, Reserpine?
1 answer-
Product No. R0875 may be stored at ambient temperature, in a cool dry place.
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What information do you have on the solubility of Product R0875, Reserpine?
1 answer-
This product is soluble in chloroform at a concentration of 50 mg/mL. It is freely soluble in chloroform (approx. 1 g in 6 mL), methylene chloride, glacial acetic acid, benzene, ethyl acetate. It is slightly soluble in acetone, methanol, alcohol (1 g/1800 mL), ether, and in aqueous solutions of acetic and citric acids. It is very sparingly soluble in water.
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What is the purity of Product R0875, Reserpine?
1 answer-
The purity of each lot is given on the Certificate of Analysis; it is typically 98% as determined by Thin Layer Chromatography (TLC).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Is Product R0875, Reserpine, synthetic?
1 answer-
The initial product is derived from Rauwolfia species; the final product is chemically synthesized.
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