P5057

Paromomycin -sulfat (Salz)

powder, suitable for cell culture, BioReagent

• Empirische Formel (Hill-System): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS-Nummer: 1263-89-4
• Molekulargewicht: 615.63 (free base basis)
• UNSPSC Code: 12352207
• PubChem Substance ID: 24898585
• NACRES: NA.76
• Beilstein/REAXYS Number: 5715182

Eigenschaften

• Produktname: Paromomycin -sulfat (Salz), powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg
• product line: BioReagent
• Quality Level: 200
• form: powder
• potency: ≥675 μg per mg
• technique(s): cell culture | mammalian: suitable
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: protein synthesis | interferes
• SMILES string: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChI key: OYJABWUHUYVDMJ-UDXJMMFXSA-N

Beschreibung

General description

Chemical structure: aminoglycoside

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Application

• Paromomycin sulfate salt has been used as a:
• reference compound in antileishmanial activity[1]
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.[2]

Recommended for use in cell culture applications at 100mg/L.

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Biochem/physiol Actions

Antimikrobielles Spektrum: Gramnegative und grampositive Bakterien, einige Protozoen-Arten und begrenzt antiparasitär.
Wirkungsweise: Hemmt die Initiation und Elongation während der Proteinsynthese.

Paromomycin hemmt die Initiation und Elongation der Proteinsynthese durch Bindung an 16S ribosomale RNA. Paromomycin bindet an der A-Stelle, wodurch defekte Polypeptidketten entstehen und zum Zelltod führen.

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

1g,5g

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable