P4365

PJ-34 hydrochloride hydrate

≥98% (HPLC), powder

• Synonym(e): PARP Inhibitor VIII, PJ 34 HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₇N₃O₂ · HCl · xH₂O
• CAS-Nummer: 344458-15-7
• Molekulargewicht: 331.80 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24898531
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to yellow
• solubility: H₂O: 22 mg/mL
• SMILES string: Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1
• InChI: 1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
• InChI key: YCALIZUKAFUQCH-UHFFFAOYSA-N

Beschreibung

Application

PJ-34 hydrochloride hydrate has been used:

• as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain[1]
• as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples[2]
• as PARP inhibitor in murine MLE-12 epithelial cell line[3]

Biochem/physiol Actions

PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.

PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.[3]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)