O8010

Okadaic acid ammonium salt from Prorocentrum concavum

≥90% (HPLC), solid

• Synonym(e): OA
• Empirische Formel (Hill-System): C₄₄H₆₈O₁₃ · NH₃
• CAS-Nummer: 155716-06-6
• Molekulargewicht: 822.03
• MDL-Nummer: MFCD00153856
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24898053
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: plant (Prorocentrum concavum)
• Qualitätsniveau: 200
• Assay: ≥90% (HPLC)
• Form: solid
• Farbe: white
• Löslichkeit: H₂O: 0.1 mg/mL; DMSO: soluble; ethanol: soluble
• Lagertemp.: −20°C
• SMILES String: [H][N+]([H])([H])[H].[H][C@]1(CC[C@@H](O)[C@@]2(O[C@@H](CC(C)=C2)C(C)\C=C\[C@@]3([H])CC[C@@]4(CCC5O[C@H]([C@@H](O)C[C@H](C)C6O[C@@]7(CCCCO7)CC[C@H]6C)C(=C)[C@@H](O)[C@]5([H])O4)O3)O1)C[C@@](C)(O)C([O-])=O
• InChI: 1S/C44H68O13.H3N/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);1H3/b10-9+;/t26-,27-,28+,30+,31+,32+,33?,34+,35-,36-,37?,38+,39-,41-,42+,43-,44-;/m1./s1
• InChIKey: ZBOMSHVRJSJGNR-JBNKPAQWSA-N

Beschreibung

Biochem./physiol. Wirkung

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311 + H331,H315
• P-Sätze: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3