O3007

Ochratoxin A−BSA conjugate from Aspergillus ochraceus

• CAS-Nummer: 303-47-9
• NACRES: NA.77
• PubChem Substance ID: 24897972
• UNSPSC Code: 12352200
• MDL number: MFCD00078079

Eigenschaften

• extent of labeling: 3-6 mol ochratoxin A per mol BSA
• Quality Segment: 200
• storage temp.: 2-8°C
• SMILES string: O=C1O[C@H](C)CC2=C(Cl)C=C(C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)C(O)=C21
• InChI: 1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
• InChI key: RWQKHEORZBHNRI-BMIGLBTASA-N

Beschreibung

Application

Ochratoxin A−BSA conjugate from Aspergillus ochraceus has been used in carbonate-bicarbonate buffer to coat the high-affinity 96-well polystyrene plates for indirect competitive enzyme-linked immunosorbent assay. It has also been used as a standard in the determination of ochratoxin A in serum by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF).

Biochem/physiol Actions

Ochratoxin A (OTA) is a mycotoxin that is the most toxic among the other ochratoxins. It is produced by Aspergillus carbonarius, A. ochraceus, and Penicillium verrucosum. OTA acts as a major food contaminant and is considered nephrotoxic, teratogenic, neurotoxic, hepatotoxic, and immunotoxic. OTA is known to elevate oxidative stress at a cellular level.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H350,H360
• pcodes: P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges