N3143

Nalidixinsäure Natriumsalz

powder

• Synonym(e): 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-carbonsäure Natriumsalz
• Empirische Formel (Hill-System): C₁₂H₁₁N₂NaO₃
• CAS-Nummer: 3374-05-8
• Molekulargewicht: 254.22
• EC Number: 222-159-7
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818602
• Beilstein/REAXYS Number: 3580062
• MDL number: MFCD00064376
• Form: powder

Eigenschaften

• sterility: γ-irradiated
• form: powder
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• SMILES string: [Na+].CCN1C=C(C([O-])=O)C(=O)c2ccc(C)nc12
• InChI: 1S/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
• InChI key: ROKRAUFZFDQWLE-UHFFFAOYSA-M

Beschreibung

General description

Chemical structure: quinolone

Application

Recommended for use in molecular biology applications at 15 μg/ml

Biochem/physiol Actions

Nalidixinsäure-Natriumsalz ist ein Inhibitor der bakteriellen DNA-Polymerase (DNA-Gyrase) und der reversen Transkriptase des aviären Myeloblastose-Virus. Hemmt die Nukleinsäure- und Proteinsynthese in Saccharomyces cerevisiae.

Preparation Note

Prepare stock solutions directly in the vial with sterile water (5-50 mg/ml). Stock solutions should be stored at −20 °C.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H317,H334,H361fd
• pcodes: P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves