N1790

Naftifin -hydrochlorid

• Synonym(e): Naftifine HCL
• Empirische Formel (Hill-System): C₂₁H₂₁N · HCl
• CAS-Nummer: 65473-14-5
• Molekulargewicht: 323.86
• MDL-Nummer: MFCD00059047
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 329818590
• NACRES: NA.76

Eigenschaften

• Assay: ≥99%
• Form: powder
• Löslichkeit: ethanol: soluble 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; fungi; yeast
• Wirkungsweise: cell wall synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23
• InChI: 1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;
• InChIKey: OLUNPKFOFGZHRT-YGCVIUNWSA-N

Beschreibung

Anwendung

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis[1].

Biochem./physiol. Wirkung

Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion[2]. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells[1].

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable