N3136

Naltrexon -hydrochlorid

≥99% (HPLC), powder, opioid receptor antagonist

• Synonym(e): Naltrexone HCl
• Empirische Formel (Hill-System): C₂₀H₂₃NO₄ · HCl
• CAS-Nummer: 16676-29-2
• Molekulargewicht: 377.86
• NACRES: NA.77
• PubChem Substance ID: 24278051
• UNSPSC Code: 12352200
• EC Number: 240-723-0
• MDL number: MFCD00069324
• Beilstein/REAXYS Number: 3580333
• Form: powder

Eigenschaften

• Produktname: Naltrexon -hydrochlorid,
• form: powder
• Quality Segment: 100
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• InChI key: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Gene Information: human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Beschreibung

Application

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves