N0290

Nitazoxanid

≥98% (HPLC)

• Synonym(e): 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)-benzamid
• Empirische Formel (Hill-System): C₁₂H₉N₃O₅S
• CAS-Nummer: 55981-09-4
• Molekulargewicht: 307.28
• EG-Nummer: 259-931-8
• MDL-Nummer: MFCD00416599
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329818424
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Ersteller: Romark
• Lagertemp.: 2-8°C
• SMILES String: CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+]([O-])=O
• InChI: 1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)
• InChIKey: YQNQNVDNTFHQSW-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Nitazoxanide (NTZ), a thiazolide compound[1] is a antiparasitic drug with structure similar to niclosamide.[2]

Anwendung

Nitazoxanide has been used:

• to test its anti-viral activity against chikungunya virus[3]
• as an antiprotozoal agent to test its effect on cell viability in various cancer cell lines[4]
• to test its effect on human cytomegalovirus (HCMV) infected human fibroblast HFF cells[5]

Biochem./physiol. Wirkung

Nitazoxanide (NTZ) promotes autophagy by acting on kinase based signaling pathways[5] and acts on mammalian target of rapamycin complex 1 (mTORC1) in Mycobacteria.[2] It has anti-viral property and effectively halts entry and release of chikungunya virus in in vitro studies.[3] NTZ also inhibits Japanese encephalitis virus (JEV) infection in early stages and has the potential to treat other viral infections including dengue, hepatitis B (HBV), coronavirus and human immunodeficiency virus (HIV).[3] It has antineoplastic functionality and may induce apoptosis by promoting proto-oncogene c-Myc inhibition resulting in tumor suppression.[1]

Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria.

Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected.

Leistungsmerkmale und Vorteile

This compound was developed by Romark. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable