SML2837

Tizoxanide

Name: Tizoxanide
Brand: SIGMA
Price: 89.3 EUR

≥98% (HPLC)

Synonym(e):

2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide, 2-Hydroxy-N-(5-nitrothiazol-2-yl)benzamide, Desacetyl-NTZ, Desacetyl-nitazoxanide, NSC 697856, NTZ metabolite, Nitazoxanide metabolite, TIZ

Slide 1 of 1

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

5 MG

€ 89,30

25 MG

€ 363,00

€ 89,30

Warenkorb auf Verfügbarkeit prüfen

Großbestellung anfragen

Über diesen Artikel

Empirische Formel (Hill-System):

C₁₀H₇N₃O₄S

CAS-Nummer:

173903-47-4

Molekulargewicht:

265.25

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD07484970

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

InChI

1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15)

SMILES string

OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1

InChI key

FDTZUTSGGSRHQF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 4

Dieser Artikel	N0290	SML0360	SML0204
Sigma-Aldrich SML2837 Tizoxanide	Sigma-Aldrich N0290 Nitazoxanide	Sigma-Aldrich SML0360 TAK-715	Sigma-Aldrich SML0204 MS-1020
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear	solubility -	solubility DMSO: >15 mg/mL	solubility DMSO: ≥10 mg/mL at 60 °C
color white to beige	color -	color faintly yellow to dark yellow	color white to tan

Biochem/physiol Actions

Active metabolite of the antimicrobial nitazoxanide (NTZ) with antiparasitic, antiviral and broad-spectrum bacterial pyruvate-ferredoxin oxidoreductase (PFOR) inhibitory efficacy.

Tizoxanide (TIZ) is the active metabolite of the broad-spectrum parasiticidal drug nitazoxanide (NTZ), a noncompetitive inhibitor against bacterial pyruvate-ferredoxin oxidoreductase (PFOR K_i 2 to 10 μM). NTZ deacetylates rapidly to TIZ in plasma (t_1/2 ~6 min at 37°C in human plasma) and in the presence of liver microsomes. NTZ is also reported to exhibit antiviral activity against Hepatitis C, Norovirus, Paramyxovirus, Influenza, Vaccinia, and Zika.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro.

Z Zhao et al.

Journal of veterinary pharmacology and therapeutics, 33(2), 147-153 (2010-05-07)

The pharmacokinetics of tizoxanide (T), the active metabolite of nitazoxanide (NTZ), and its protein binding ability in goat plasma and in the solutions of albumin and alpha-1-acid-glycoprotein were investigated. The plasma and protein binding samples were analyzed using a high-performance

Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni.

Paul S Hoffman et al.

Antimicrobial agents and chemotherapy, 51(3), 868-876 (2006-12-13)

Nitazoxanide (NTZ) exhibits broad-spectrum activity against anaerobic bacteria and parasites and the ulcer-causing pathogen Helicobacter pylori. Here we show that NTZ is a noncompetitive inhibitor (K(i), 2 to 10 microM) of the pyruvate:ferredoxin/flavodoxin oxidoreductases (PFORs) of Trichomonas vaginalis, Entamoeba histolytica

Activity of nitazoxanide and tizoxanide against Mycobacterium tuberculosis in vitro and in whole blood culture.

Elizabeth P Harausz et al.

Tuberculosis (Edinburgh, Scotland), 98, 92-96 (2016-05-10)

Nitazoxanide (NTZ) and its metabolite tizoxanide (TIZ) were studied as antimycobacterial agents in vitro (in mycobacterial growth indicator tube [MGIT] cultures) and in a whole blood bactericidal assay. Both NTZ and TIZ show high protein binding. In MGIT cultures (albumin concentration = 78 μM)

Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses.

A Stockis et al.

International journal of clinical pharmacology and therapeutics, 40(5), 213-220 (2002-06-08)

Nitazoxanide (N) is a new broad-spectrum intestinal antiparasitic agent. Deacetyl-N or tizoxanide (T) and its glucuronide (TG) are the major circulating species metabolites after oral administration of N. Bioavailability is substantially increased by food. The objectives of this phase IA

Nitazoxanide: pharmacokinetics and metabolism in man.

J Broekhuysen et al.

International journal of clinical pharmacology and therapeutics, 38(8), 387-394 (2000-09-13)

Nitazoxanide (N), a new broad-spectrum parasiticidal agent, is rapidly deacetylated to tizoxanide (T). The objective of the study was to determine if metabolites other than T are present in the plasma and excreted after single dose oral administration of radiocarbon-labelled

Alle zugehörigen Dokumente anzeigen

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung

Tizoxanide