M1559

Moxonidine hydrochloride

≥98%

• Synonym(e): 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride, BDF-5895
• Empirische Formel (Hill-System): C₉H₁₂ClN₅O · HCl
• CAS-Nummer: 75438-58-3
• Molekulargewicht: 278.14
• NACRES: NA.77
• PubChem Substance ID: 24278537
• UNSPSC Code: 12352200
• MDL number: MFCD06795643
• Assay: ≥98%

Eigenschaften

• Quality Segment: 100
• assay: ≥98%
• originator: Solvay
• SMILES string: Cl.COc1nc(C)nc(Cl)c1NC2=NCCN2
• InChI: 1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
• InChI key: ZZPAWQYZQVUVHX-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), NISCH(11188)

Beschreibung

Application

Moxonidine hydrochloride has been used:

• as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method[1]
• as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC)
• as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN)[2]

Biochem/physiol Actions

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently.[3] Moxonidine also exhibits spinal analgesic activity through the α_2C-adrenoceptor component.[4]

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Solvay. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)
• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H336
• pcodes: P261 - P264 - P271 - P301 + P310 + P330 - P304 + P340 + P312 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• target_organs: Central nervous system