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K3750

L-Kynurenine sulfate salt

≥98% (HPLC), suitable for ligand binding assays

Synonym(e):

β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

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Über diesen Artikel

Lineare Formel:
C10H12N2O3 · H2SO4
CAS-Nummer:
Molekulargewicht:
306.29
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
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Produktname

L-Kynurenine sulfate salt, crystalline

assay

≥98% (HPLC)

Quality Segment

form

crystalline

technique(s)

ligand binding assay: suitable

color

light yellow

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.N[C@@H](CC(=O)c1ccccc1N)C(O)=O

InChI

1S/C10H12N2O3.H2O4S/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15;1-5(2,3)4/h1-4,8H,5,11-12H2,(H,14,15);(H2,1,2,3,4)/t8-;/m0./s1

InChI key

KAXRWMOLNJZCEW-QRPNPIFTSA-N

Application

L-Kynurenine sulfate salt has been used as a substrate to study the enzyme activity of kynurenine aminotransferase. It has also been used in the synthesis of Kyn adducts of certain amino acids .

Biochem/physiol Actions

L-Kynurenine (L-Kyn) is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mammals, it modulates the transmission of glutamate neurotransmitter. It is also considered to be a sex-attracting pheromone in vertebrates.
Key intermediate in the breakdown pathway of tryptophan.
L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. L-kynurenine is involved in a variety of neurological processes and diseases. L-kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.

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Dieser Artikel
K8625D0754S7129
form

crystalline

form

powder

form

crystalline

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

≥98.0% (TLC)

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

ligand binding assay: suitable

technique(s)

ligand binding assay: suitable

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

−20°C

color

light yellow

color

-

color

white

color

white

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100


Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Questions

  1. Is it possible to get this in a smaller size (50-100 mg) as a demo? I would like to test that this is soluble for our project's application (ideally more soluble in aqueous solutions the L-kyn)?

    1 answer
    1. 500MG is the smallest available package size for the product. Its quality specifications include a test for solubility in water at 1% (10 mg/ml).
      K8625 L-Kynurenine (free acid vs Sulfate salt) is sold in 25MG and 100MG package sizes, but its solubility in water is limited; it is best dissolved in 0.5M Hydrochloric acid.

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