I6410

ISCK03

≥98% (HPLC), solid

• Synonym(e): Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl], [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide
• Empirische Formel (Hill-System): C₁₉H₂₁N₃O₂S
• CAS-Nummer: 945526-43-2
• Molekulargewicht: 355.45
• NACRES: NA.77
• PubChem Substance ID: 329815393
• UNSPSC Code: 12352200
• MDL number: MFCD12031591
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: DMSO: ≥20 mg/mL, H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3
• InChI: 1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3
• InChI key: XQABBHBFHWHMKF-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner.

ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner. ISCK03 inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells. Complete inhibition was observed with 1 and 5 μM ISCK03.

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves